Drug Safety Reference
PillID
Drug Interactions
Drug Interactions Guide
Clinically accurate guides to 30 common drug combinations — covering the mechanism behind each interaction, who is at risk, what symptoms to watch for, and what to do. Organized by category, searchable by name.
No interactions match your search.
Alcohol Interactions
Alcohol · Antibiotic
Alcohol and Metronidazole
Disulfiram-like reaction — flushing, vomiting, rapid heartbeat
Major
Read guide →
Alcohol · SSRI
Alcohol and Sertraline
CNS depression, impaired judgment, mood destabilization
Moderate
Read guide →
Alcohol · Anticonvulsant
Alcohol and Gabapentin
Additive CNS depression, respiratory sedation risk
Major
Read guide →
Alcohol · Analgesic
Alcohol and Acetaminophen
Liver toxicity risk — CYP2E1 induction and glutathione depletion
Major
Read guide →
Alcohol · Anticoagulant
Alcohol and Warfarin
Unpredictably alters INR — bleeding or clotting risk
Major
Read guide →
Alcohol · Benzodiazepine
Alcohol and Lorazepam
Life-threatening respiratory depression — CNS synergy
Major
Read guide →
Alcohol · Antibiotic
Alcohol and Amoxicillin
Myth busted — no direct interaction but impairs immune recovery
Minor to Moderate
Read guide →
Alcohol · Diabetes Medication
Metformin and Alcohol
Risk of lactic acidosis in heavy drinkers
Moderate
Read guide →
Alcohol · Antidepressant
Wellbutrin and Alcohol
Lowered seizure threshold — particularly dangerous for bupropion
Major
Read guide →
Alcohol · Antidepressant
Trazodone and Alcohol
Amplified sedation, dizziness, and CNS depression
Moderate
Read guide →
Alcohol · Sleep Supplement
Melatonin and Alcohol
Excessive sedation, disrupted sleep architecture
Moderate
Read guide →
Alcohol · Opioid
Hydrocodone and Alcohol
Fatal respiratory depression — never combine opioids and alcohol
Major
Read guide →
SSRI · Opioid
Sertraline and Tramadol
Serotonin syndrome risk — potentially life-threatening
Major
Read guide →
SSRI · Benzodiazepine
Sertraline and Alprazolam
CNS depression, alprazolam levels increased by sertraline
Moderate
Read guide →
SSRI · Opioid
Fluoxetine and Tramadol
Serotonin syndrome + reduced tramadol efficacy via CYP2D6
Major
Read guide →
SSRI · NSAID
Sertraline and Ibuprofen
Increased GI bleeding — SSRIs deplete platelet serotonin
Moderate
Read guide →
Stimulant · SSRI
Adderall and Zoloft
Serotonin and cardiovascular interactions — monitor carefully
Moderate
Read guide →
NSAID · NSAID
Ibuprofen and Naproxen
Doubled GI bleed risk, no added benefit — never combine two NSAIDs
Major
Read guide →
Anticoagulant · NSAID
Warfarin and Ibuprofen
Triple bleeding threat — one of the most dangerous OTC+Rx combos
Major
Read guide →
NSAID · Analgesic
Ibuprofen and Acetaminophen
Generally safe to combine — different mechanisms, additive relief
Compatible (with caution)
Read guide →
ACE Inhibitor · NSAID
Lisinopril and Ibuprofen
Reduced antihypertensive effect + acute kidney injury risk
Major
Read guide →
ACE Inhibitor · ARB
Lisinopril and Losartan
Dual RAAS blockade — hypotension, hyperkalemia, kidney injury
Major
Read guide →
ACE Inhibitor · Electrolyte
Lisinopril and Potassium
ACE inhibitors retain potassium — supplements can cause hyperkalemia
Major
Read guide →
Beta Blocker · Calcium Channel Blocker
Metoprolol and Verapamil
Bradycardia and heart block — dangerous cardiac conduction synergy
Major
Read guide →
Statin · Food
Atorvastatin and Grapefruit
Grapefruit inhibits CYP3A4 — elevated statin levels, myopathy risk
Moderate
Read guide →
Statin · Calcium Channel Blocker
Simvastatin and Amlodipine
Amlodipine increases simvastatin exposure — myopathy risk
Moderate
Read guide →
Antibiotic · Antacid / Supplement
Ciprofloxacin and Antacids
Chelation reduces absorption by up to 90% — separate by 2–6 hours
Major
Read guide →
Antibiotic · Food
Doxycycline and Dairy
Dairy calcium chelates doxycycline — avoid around dose times
Moderate
Read guide →
Thyroid Hormone · Supplement
Levothyroxine and Calcium
Calcium reduces levothyroxine absorption — separate by 4+ hours
Moderate
Read guide →
Anticonvulsant · Opioid
Gabapentin and Hydrocodone
Additive respiratory and CNS depression — overdose death risk
Major
Read guide →